July 2018: BioBreakfast

Tuesday, July 17  

7:30 - 9:30 AM

Highlighting Innovative Research at Christiana Care Health System

Connectivity and collaborations are driving innovation in the First State! Join Delaware Bio on Tuesday, July 17th for our next BioBreakfast at Christiana Care Health System John H. Ammon Medical Education Center. Hear from Eric Kmiec, Ph.D., of Christiana Care’s Gene Editing Institute at the Helen F. Graham Cancer & Research Institute, Dominique Medaglio, Ph.D., of the Value Institute at Christiana Care, and Scott D. Siegel, Pd.D., also of the Value Institute.

You will not want to miss this opportunity to learn more about Christiana Care’s innovative research for the betterment of the local community.

Grab a coffee, bring your business cards, and connect with Delaware’s life science industry leaders at our July BioBreakfast!

For questions or more information, contact Jamie Pedrick at [email protected].

Eric Kmiec, Ph.D.

Director, Gene Editing Institute
Helen F. Graham Cancer & Research Institute
Christiana Care Health System

Eric Kmiec, Ph.D., is well known for his pioneering work in the fields of molecular medicine and gene editing. Since 2014 he has directed the Gene Editing Institute of the Helen F. Graham Cancer Center & Research Institute at Christiana Care Health System.

Under Dr. Kmiec’s leadership, the Gene Editing Institute has become a leader in gene editing and biomedical research in cancer and other inherited disease. It is the only institute of its kind embedded in a community cancer center where interactions among oncologists, genetic counselors and patients take place. This unique collaboration brings translational cancer research – from innovative basic science directly to patient treatment – to an entirely new level.

Throughout his professional career, Dr. Kmiec has led research teams studying the reaction mechanics, biochemistry and molecular genetics of gene editing in human cells. His early work with sickle cell disease led to research and development of the next generation of gene editing tools, including CRISPRs (clustered regularly interspaced short palindromic repeats) and to even more promising variations such as single-stranded DNA oligonucleotides (ssODNs) for the treatment of inherited disorders.

In April 2018, the team announced a major new development in the CRISPR Journal of the first CRISPR gene-editing tool to allow DNA repairs outside the human cell. The new “cell free” technology uses a protein called Cpf1 or Cas12a, that allows researchers to make multiple edits to DNA samples quickly and more precisely in vitro, that is, in a test tube or petri dish. This capability has generated unprecedented excitement about developing different CRISPR tools that could produce breakthrough treatments for a wide range of diseases by repairing a damaged gene, modifying it or deleting it entirely.

Dr. Kmiec is the recipient of multiple research awards from the National Institutes of Health (RO1s, R21s), the American Cancer Society, the Binational Industrial Research and Development (BIRD) Foundation and other private foundations including the 2012 Proudford Foundation Unsung Hero Award in Sickle Cell Disease. He has been a member of numerous editorial boards, NIH study sections and review boards and is the (primary or corresponding) author of more than 155 scientific publications (mostly in genetic recombination and gene editing).

He holds 18 issued patents, most of which have been licensed by biotechnology and pharmaceutical companies and has founded two biotechnology companies. He is a senior scientific advisor and SAB member of ETAGEN, a gene editing company located in Cambridge, Massachusetts, centered on the development of therapeutic uses of gene editing.

Dr. Kmiec has been the primary mentor for 18 Ph.D. students and 4 MS students, all of whom have attained scientific positions. He has held or holds major administrative posts on various NIH regional and state biomedical research grants, including IDeA Network of Biomedical Research (INBRE) and Centers of Biomedical Research Excellence (COBRE). Dr. Kmiec was also honored as the Eminent Scholar in residence at Marshall University (Huntington, West Virginia) in 2009-2011 and was elected as an Honorary Commander of the 436th Air Wing at Dover Air Force Base in Dover, Delaware for in 2013 and again in 2014.

Dominique Medaglio, PharmD

Senior Clinical Researcher
Value Institute
Christiana Care Health System

Dr. Medaglio is a Senior Clinical Researcher for the Value Institute at Christiana Care Health System. She has a PharmD from the University of Kentucky College of Pharmacy, where she conducted research focusing on health literacy and cost effectiveness analysis. She also has an MS in Health Policy and completed a postdoctoral fellowship in Health Economics and Outcomes Research at the Jefferson College of Population Health in Philadelphia (JCPH). Her work and experience at JCPH focused on hospital quality, medication prescribing and utilization, and healthcare reform. She is the recipient of the 2012 PhRMA Foundation Postdoctoral Fellowship in Health Outcomes for her work examining linked pharmacy claims to the electronic health record (conducted at Christiana Care). She is also the recipient of a Delaware CTR Pilot grant, which focuses on medication adherence after hospital discharge.  Her current research interests center on optimizing medication use from clinical, economic, and policy perspectives.

Scott D. Siegel, Ph.D.

Director, Population Health Psychology
Value Institute
Christiana Care Health System

Scott D. Siegel, Ph.D., M.H.C.D.S., is a licensed psychologist and the Director of Population Health Psychology within the Value Institute at the Christiana Care Health System in Newark, DE. In this role, Dr. Siegel works collaboratively with multidisciplinary teams in the health system and across sectors, including local and state governments, academic partners, and community-based organizations, to address the social and behavioral determinants of the health in our local communities. In his immediate prior role, Dr. Siegel served at the Director of Psychosocial Oncology & Survivorship at the Helen F. Graham Cancer Center & Research Institute (Christiana Care), where he provided counseling services to people affected by cancer and led a team of psychologists, social workers, nursing, and research staff.

Dr. Siegel is an Adjunct Associate Professor within the Department of Psychological & Brain Sciences at the University of Delaware and holds an appointment as a Research Associate Professor within Psychiatry & Human Health at the Sidney Kimmel Medical College at Thomas Jefferson University. Dr. Siegel is an author on over 40 peer-reviewed research articles, book chapters, and published abstracts and has been an investigator on multiple federal grants funded by the National Institutes of Health. He completed his B.A. in psychology at Rutgers University and his M.S. and Ph.D. in clinical health psychology at the University of Miami, with a clinical internship at the Puget Sound VA Health Care System in Seattle, WA. In addition, in 2018 Dr. Siegel completed his Master of Health Care Delivery Science at Dartmouth, a joint program of the Tuck School of Business and the Dartmouth Institute for Health Policy and Clinical Practice.


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